Take Very Good
Care of YouselvesDeuteronomy 4:15





BS'D


style="mso-ansi-language: EN-AU" lang=EN-AU>face="Times New Roman">News in Science


lang=EN-AU>Diabetes/Lifestyle
link


lang=EN-AU>Lifestyle creating more type 1
diabetics


style="FONT-SIZE: 12pt; mso-ansi-language: EN-AU" lang=EN-AU>face="Times New Roman">For a long time we are hearing about the link between
lifestyle and Type 2 diabetes.  Now
research is showing a growing link between lifestyle and Type 1
diabetes



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lang=EN-AU>Diet and lifestyle may be
playing a bigger role in the development of childhood type 1 diabetes
(Source: iStockphoto)


lang=EN-AU>A jump in the number of
'lower-risk' children being diagnosed with type 1 diabetes, has contributed to a
doubling in the number of cases over the past 20 years, say Australian
researchers.


face="Times New Roman">Endocrinologist Dr Spiros Fourlanos from the href="http://www.mh.org.au/royal_melbourne_hospital/" target=_blank>face="Times New Roman">Royal Melbourne Hospitalface="Times New Roman"> and his colleagues report their findings in href="http://care.diabetesjournals.org/" target=_blank>face="Times New Roman">Diabetes Careface="Times New Roman">, which suggests environmental factors, such as sedentary
lifestyle, may be the cause.


style="mso-ansi-language: EN-AU" lang=EN-AU>Previous research has found the
incidence of children diagnosed with type 1 diabetes has doubled in
lang=EN-AU>Australiastyle="mso-ansi-language: EN-AU" lang=EN-AU> over the past two decades.


face="Times New Roman">In previous decades people with intermediate or low risk
human leukocyte antigen (HLA) genes were least likely to progress to diabetes in
childhood.


face="Times New Roman">But the new study suggests a growing number of children
diagnosed with type 1 diabetes have intermediate risk HLA
genes.


face="Times New Roman">The study examined 462 Victorians who had been diagnosed
with childhood type 1 diabetes since 1950.


face="Times New Roman">Between 1950 and 1969, 79% of children diagnosed with
type 1 diabetes high risk HLA genes. In the period 2000 to 2005, this had
dropped to 28%. Simultaneously those with intermediate risk HLA genes jumped
from 20% to 48%, those with low risk genes remained stable at 3%.


style="mso-ansi-language: EN-AU" lang=EN-AU>"We found that surprisingly type 1
diabetes was starting to develop more often in the lower risk groups - occurring
increasingly in those with intermediate risk genes. Previously this was much
less common," co-researcher and
style="mso-ansi-language: EN-AU" lang=EN-AU>Royalstyle="mso-ansi-language: EN-AU" lang=EN-AU> style="mso-ansi-language: EN-AU"
lang=EN-AU>Melbourne
style="mso-ansi-language: EN-AU" lang=EN-AU> style="mso-ansi-language: EN-AU"
lang=EN-AU>Hospital
style="mso-ansi-language: EN-AU" lang=EN-AU> director of diabetes and
endocrinology, Professor Peter Colman says.


face="Times New Roman">"High risk genes used to account for most cases but now
more are lower risk genes."


lang=EN-AU>Sedentary
lifestyle


face="Times New Roman">Researchers believe environmental factors including
obesity, reduced exercise or vitamin D deficiency due to reduced sunlight
exposure, could be interacting with the HLA genes trigger childhood type 1
diabetes.


face="Times New Roman">Colman says that while the link between childhood obesity
and type 2 diabetes is well known, researchers now believe lifestyle factors may
also contribute to type 1 diabetes.


lang=EN-AU>Getting
younger


face="Times New Roman">He adds that the average age of children diagnosed with
type 1 diabetes with either immediate or low risk HLA genes, had decreased from
eight and half years old, to six years old.


face="Times New Roman">Colman cautions that "still only a small proportion of
those who have the HLA genes will develop type 1
diabetes."


face="Times New Roman">"However disease incidence and the ratio of intermediate
to high risk genes is continuing to increase so there is a much larger pool of
people with this genetic risk type, meaning a bigger possible pool of people who
can potentially develop diabetes," he says.


face="Times New Roman">Colman says 3% of first degree relatives (i.e. sisters
and brothers) of those diagnosed with type 1 diabetes will develop the disease.
As a result, an increasing number of siblings are being tested, in the hope new
future treatments such as intra-nasal and oral insulin, or gene therapy, could
prevent its progression.


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